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Asian Journal of Biological Sciences
Year: 2012  |  Volume: 5  |  Issue: 6  |  Page No.: 322 - 327

Methanolic Extract of Musa sapientum (L var. paradisiaca) Sucker Improves Lipid Profiles in Alloxan Induced Diabetic Rats

B.A. Salau and E.O. Ajani    

Abstract: Alterations in plasma lipid profiles are common occurrences in diabetes. There is also a positive correlation between the risk of developing ischaemic heart disease and raised plasma cholesterol and LDL-cholesterol. Musa sapientum sucker extract has proven to be an effective antidiabetic agent by lowering blood sugar level and improve the islets of Langerhans. In this study, effect of different concentrations of methanolic extracts of Musa sapientum sucker on plasma lipid profile were assessed in alloxan induced diabetic rats. Total plasma cholesterol, HDL cholesterol and triglyceride were determined using enzymatic kits, while plasma LDL cholesterol, VLDL cholesterol, atherogenic and coronary risk indices were calculated. The extract at 5 mg and 10 mg/kg/body weight/day reduced significantly (p<0.05) the total plasma cholesterol, very low density lipoprotein cholesterol and plasma triglyceride. Administration of the extract also reduced significantly (p<0.05) the atherogenic and coronary risk indices. However, a significant increase (p<0.05) was observed in plasma HDL cholesterol. The result of the study indicates that Musa sapientum sucker extract was effective in improving plasma lipid profile associated with cardiovascular risk factors in alloxan induced diabetic rats.

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