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Asian Journal of Biological Sciences
Year: 2011  |  Volume: 4  |  Issue: 8  |  Page No.: 591 - 600

Anti-spermatogenic Activity of Butea monosperma (Lam.) Kuntze Root

Neeru Vasudeva, Geeta Rai and Surendra Kr. Sharma    

Abstract: Butea monosperma is a commonly used plant in folk medicine in Indian subcontinent. The present investigation was undertaken to examine the anti-spermatogenic activity of the four successive extracts i.e., petroleum ether, chloroform, methanol and aqueous extracts of the root of B. monosperma. The in vitro studies on human sperms revealed that the petroleum ether and chloroform extracts at the concentration of 15 mg mL-1 caused significant immobilisation and reduction of sperm viability. The extracts caused irreversible damage to the sperms. Further, the effect of these extracts was assessed on the testis and epidydmis of the male albino mice at the dose of 200 mg kg-1 body weight. A significant decrease in the weight and changes in fructose, alkaline phosphate, total protein and cholesterol level in these organs of the treated mice when compared to control mice was observed. Histological studies of these organs were also performed.

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