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American Journal of Biochemistry and Molecular Biology
Year: 2013  |  Volume: 3  |  Issue: 3  |  Page No.: 336 - 340

Effect of Radiotherapy on Tissue Damage, Innate and Humoral Immunity in Malignant Condition

Arpita Chatterjee and Gopeswar Mukherjee    

Abstract: Radiation oncology is a widely accepted subject in all over the world for the treatment of malignancy. To study the innate as well as humoral immune response before and after radiation therapy in patients and also to estimate the level of tissue damage in them the present study was performed. The extent of tissue damage was determined by measuring the C-reactive protein and immunologic defense was estimated by measuring complement C3 for innate resistance and immunoglobulin IgG for the humoral response. The complement C3, IgG and C-reactive protein levels of cancer patients were significantly higher than the normal level. More increase in serum C-reactive protein level in every patient after radiotherapy was observed. In majority of the cases decrease of C3 and IgG level was estimated after prolonged radiation treatment. This indicated that radiation therapy, despite being a successful treatment for cancer, causes massive tissue damage; and cellular as well as humoral immunity remains at a low level after radiotherapy. Age is a crucial factor to tolerate such prolonged therapy treatment. Prolonged application of radiotherapy may also cause side effects on normal immune system as they are already in immune deficient state due to the life threatening neoplastic disease.

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