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American Journal of Biochemistry and Molecular Biology
Year: 2013  |  Volume: 3  |  Issue: 1  |  Page No.: 119 - 126

Modulation of Cardiovascular Risk Factors (Haematological and Haemorrheological Parameters) Caused by Sucrose Diet

B.A Salau, A.O. Ketiku, O.L. Adebayo, W.E. Olooto, E.O. Ajani and O. Osilesi    

Abstract: The involvement of sucrose and its amount in the causation of cardiovascular disease is still controversial and inconclusive. The two latest reports of WHO/FAO and Institute of Medicine of Food and Nutritional Board (IOM of FNB) on optimal level of sucrose consumption are at least contradictory; therefore the need to clarify the effect of different concentrations of sucrose consumption on cardiovascular disease risk factor is expedient. Effect of sucrose consumption was assessed on twenty four male albino rats, four to six weeks old, 48-65 g, divided into five groups: G1 (control), G2 (10% energy supply from sucrose), G3 (20% energy supply from sucrose), G4 (30% energy supply from sucrose). The following parameters were determined: red blood cell count, white blood cell count, packed cell volume, blood and plasma viscosities; fibrinogen level and erythrocyte sedimentation rate. Analyses revealed that inclusion of sucrose at concentration of 20% energy supply significantly increased (p<0.05) blood viscosity by 97.59%, plasma viscosity 16.48%, erythrocyte sedimentation rate 40.00%, plasma fibrinogen13.63% and white blood cell count 6.59%, while no significant effect (p>0.05) was observed on red blood cell count and packed cell volume. The study revealed that consumption of sucrose at twenty percent energy supply increased some selected haematological and haemorrheological parameters associated with cardiovascular disease.

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