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Asian Journal of Biotechnology
Year: 2011  |  Volume: 3  |  Issue: 1  |  Page No.: 22 - 37

Sperm DNA Bridges from Sperm to Egg to Inculcate Genetic Variability: A Review

S. Mishra and S. Nanda    

Abstract: Sperm DNA fragmentation is known to compromise male fertility. The data entail that sperm DNA damage can be efficiently treated with oral antioxidant administration during a relatively short time period. It is an understanding that the 2 types of DNA appear to be distinct and independently packaged molecules; however, research has demonstrated the symbiotic nature of these structures in contributing to male infertility. Data must continue to be gathered to establish strong correlations between traditional semen analysis parameters and sperm DNA integrity; this information remains controversial and useless in clinical practice until new techniques for the diagnosis and treatment of sperm DNA can be established. More modern technology must be employed to correlate such information into useful clinical knowledge. This study is the compilation of reports pertaining to research on sperm DNA biochemistry and molecular biology to establish an opinion that sperm DNA integrity is both extremely fragile and exceedingly important for male fertility.

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