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Asian Journal of Biotechnology
Year: 2009  |  Volume: 1  |  Issue: 1  |  Page No.: 12 - 19

Hepatoprotective Potential of Calcium and Magnesium Against Cadmium and Lead Induced Hepatotoxicity in Wistar Rats

J.D. Dabak, S.Y. Gazuwa and G.A. Ubom    

Abstract: This study was designed to investigate the hepatoprotective potential of calcium and magnesium against lead and cadmium induced hepatotoxicity using a rat model. Varying concentrations of cadmium and lead salts in combination were used to induce liver damage. This was followed by adding varying concentrations of calcium and magnesium salts in combination to the same concentration used to induce liver damage. The degree of damage and protection were measured using biochemical parameters such as serum-glutamate-pyruvate transaminases (SGPT), serum-glutamate-oxaloacetate transaminases (SGOT), total protein, albumin and histopathological examination of the liver cells. Studies indicate that liver function is generally impeded particularly with respect to albumin synthesis and the cellular integrity of the organ is damaged as a function of elevations in cadmium and lead concentrations. The albumin concentration decreased as the concentrations of cadmium and lead were increased from control thus: 4.25±0.40 g/100 mL; 3.63±0.17 g/100 mL; 3.50±0.13 g/100 mL; 3.38±0.19 g/100 mL and 3.38±0.29 g/100 mL, respectively, while SGPT and SGOT were increasing. The addition of calcium and magnesium to the same combined concentrations of cadmium and lead which caused albumin synthesis impairment in the first phase of this research protected the liver as the albumin concentrations were not significantly different from control. The albumin concentrations were: 3.70±0.18 g/100 mL; 3.88±0.38 g/100 mL; 3.75±0.18 g/100 mL; 3.60±0.44 g/100 mL and 3.88±0.36 g/100 mL, respectively. Histopathological studies on the liver confirmed the protective potential of calcium and magnesium on the hepatotoxicity arising from cadmium and lead as the damage observed in phase 1 of this research using the same concentrations is obliterated.

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