Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Asian Journal of Biochemistry
Year: 2015  |  Volume: 10  |  Issue: 2  |  Page No.: 67 - 77

Sub-Chronic Oral Esculetin (6, 7-Dihydroxy-Coumarin) Exposure in Male Wistar Rats: Effect on Some Serum Functions and Organ Histology

Cemaluk C. Egbuonu Anthony, Ambrose E. Ogbu and Lawrence U.S. Ezeanyika    

Abstract: The study assessed the effect on some serum functions and organ histology following esculetin exposure in rats. Five groups (n = 6) of Wistar rats respectively received (A) 6.0 mg kg-1 body weight (b.wt.), (B) 12.0 mg kg-1 b.wt. (C) 24.0 mg kg-1 b.wt. of esculetin, (D, vehicle control) 0.2 mL kg-1 b.wt. of 10% dimethylsulfoxide, DMSO and (E, normal control) 0.2 mL kg-1 b.wt. of Distilled Water (DW) per orally and daily for 28 days. On comparison with the controls, a dose dependent and significant (p<0.05) decrease in the concentration of serum sodium ion (141.00±5.02 mmol L-1) but an increase in that of potassium ion (9.39±3.24 mmol L-1) was observed in the group C rats. The decrease in the serum protein concentration (6.58±0.77 mmol L-1) in the group C rats, though dose dependent, was not significant (p>0.05). In the group C rats, the decrease (p<0.05) in the serum urea concentration (10.95±0.61 mmol L-1) was dose dependent but the increase (p<0.05) in the serum creatinine concentration (85.87±8.31 mmol L-1) was not dose dependent. Histological examination revealed a severely dilated hepatic vein (A) and proliferated cells around the bile canaliculi (B) in group C rats. Other organs examined (kidney, testis, brain and heart) did not show any lesion in the test groups. The results showed that the esculetin-induced improvement in the serum parameters might not alter the studied organ histology in the rats, especially at the lower tested concentrations.

Cited References   |    Fulltext    |   Related Articles   |   Back
  Related Articles

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility