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Asian Journal of Biochemistry
Year: 2014  |  Volume: 9  |  Issue: 3  |  Page No.: 151 - 169

Prevention of Oxidative Damage of Liver, Kidney and Serum Proteins with Apoptosis of above Tissues in Guinea Pigs Fed on Carbonated Soft Drink by Vitamin C

P. Banerjee and K. Panda    

Abstract: Damages of liver, kidney and serum proteins with apoptosis of these tissues in guinea pigs fed on carbonated soft drink was reported earlier. The present study establish the fact that if antioxidant supplementation is made along with carbonated soft drink such damages could be prevented. Vitamin C is a potent antioxidant and guinea pigs cannot synthesise ascorbic acid like mice. Excess sugar in carbonated soft drink increases production of destructive free radicals in animal. Ascorbic acid was supplemented orally in a measured dose along with carbonated soft drink, also in a measured volume to guinea pigs during the experimental period. Though oxyblot assay, fluorescence activated cell sorting assay and other biochemical findings, this paper reports that oxidative damages of the tissues along with apoptosis under the condition of carbonated soft drink feeding to guinea pigs could be prevented with supplementation of ascorbic acid.

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