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Asian Journal of Biochemistry
Year: 2012  |  Volume: 7  |  Issue: 2  |  Page No.: 98 - 105

Effect of Calorie Restriction Supplemented with Genistein on Serum Levels of Glucose, Lipid Profile and Inflammatory Markers (Resistin and hsCRP) in Obese Rats

M.Mohammad- Shahi, H. Rafiei, M. Karandish, K. Omidian and F. Haidari    

Abstract: It seems that soy isoflavones can improve obesity and reverse subsequent metabolic disorders. In this study we assessed the effect of restriction of calorie supplemented with genistein on diet-induced obese rats. Thirty male Wistar obese rats were divided randomly into 3 experimental groups (n = 10) as follows: group 1: low calorie diet supplemented with 50 mg kg-1 genistein, group 2: low calorie diet supplemented with dimethyl sulphoxide (as vehicle) and group 3: obese control rats with ad libitum access to standard food. The animals were carefully monitored and weighed daily. After 4 weeks, fasting blood samples were collected and analyzed for biochemical analysis. The results showed that the restriction of calorie intake caused to weight loss and subsequently led to a significant decrease in serum glucose (p<0.001), lipid profile (p<0.001) and hsCRP levels (p<0.001) but had no effect on resistin levels. Although, low calorie diet supplemented with genistein improved the lipid lowering effect of calorie restriction but this had no more effect on glucose, resistin and hsCRP levels. These results strongly suggest that low calorie diet supplemented with genistein is effective in weight management and has hypoglycemic, hypolipidemic and anti-inflammatory activities. However, it is not recommended before further investigations in animals and humans.

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