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Asian Journal of Biochemistry
Year: 2011  |  Volume: 6  |  Issue: 5  |  Page No.: 416 - 425

Effect of Dialysis on Heme Oxygenase-1 (HO-1) Expression in Peripheral Blood Leukocytes of End Staged Renal Diseased Patients

Sathyapriya Kandavelu and Parameswari Chetenchery Somasundaram    

Abstract: Many End staged Renal Diseased and hemodialysis patients are in a state of chronic inflammation induced by the dialysis process which further enhances oxidative stress. The study aim was to explore the critical role of Heme oxygenase-1, a potent antioxidant, in patients subjected to various dialysis conditions. The study population contained randomly selected end-staged renal failure patients (n = 64) who have been treated by hemodialysis for at least 6 months, between the age group of 20-50 with creatinine levels greater than 5 mg dL-1. About 20 samples were collected from predialysis patients, 22 samples were collected from patients undergoing dialysis and 22 samples were collected from post dialysis patients. The samples were subjected to antioxidant enzyme analysis followed by flow cytometric and immunoflouroscence studies HO-1 expression was found to be elevated in all the dialysis conditions but higher elevation was observed in post dialysis patients. The results suggest that HO-1 might have some link with the disease progression and though upregulated like other stress proteins, it’s antioxidant capacity has been ineffective to cease the disease invasion.

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