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Asian Journal of Biochemistry
Year: 2008  |  Volume: 3  |  Issue: 1  |  Page No.: 32 - 37

Oxidative Stress in the Liver of Diabetic Rats Treated with a Combination of Sildenafil Citrate and a Free Radical Scavenger

N.M Abdel-Hamid, L.M Faddah, M.A Al-Rehany and A.A Awad    

Abstract: Erectile Dysfunction (ED) is a common problem within diabetic patients. The liver is one of the most affected vital organs by diabetic consequences. Oxidative stress is the most known intermediary pathway initiating liver diseases among diabetics. The present study was designed to investigate the protective effect of alpha toccopherol (α-TP) against possible oxidative stress, that may be elicited by administration of Sildenafil Citrate (SC) and to assess whether SC may negatively affect the liver in an experimental diabetic model. SC was given to groups of normo-glycemic and diabetic rats, either alone or in combination with α-TP, by oral route for two weeks. Hepatic tissue content of malondialdehyde-a thiobarbituric acid reactive oxygen species (TBARS) and reduced glutathione (GSH) were determined as biomarkers for oxidative stress in liver tissue. TBARS was significantly up-regulated in diabetic than normo-glycemic rats. SC significantly down-regulated TBARS content, an effect which was synergized by α-TP co-administration. SC treatment depleted GSH in both normo-glycemic and hyperglycemic rats, this effect was completely reversed by α-TP co-administration. α-TP could not correct the effect of diabetes on liver GSH and TBARS contents and it couldn`t restore theses parameters in diabetic to non-diabetic values. In conclusion, our study explored the usefulness of α-TP co-administration in protecting the liver against GSH depletion, induced by SC administration. We also elucidated that SC down-regulated TBARS in liver tissue, an effect which was potentiated by α-TP co-administration. We recommend the use of α-TP as an adjuvant therapy to SC, specially for diabetic patients who are considered to be the most extensive users of the drug.

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