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Asian Journal of Biochemistry
Year: 2008  |  Volume: 3  |  Issue: 5  |  Page No.: 315 - 319

Lipid Peroxidation and Total Antioxidant Capacity in Patients with Chronic Renal Failure

D.R. Suresh, C.R. Wilma Delphine Silvia and Rajni Agarwal    

Abstract: This study was carried out to assess the status and correlation between lipid peroxidation and antioxidant status in CRF patients. Forty predialytic CRF patients, of either sex and age >25 years with serum creatinine levels >3.0 mg dL-1 and forty healthy controls were included in the study. Serum MDA levels were estimated by colorimetric method and Total Antioxidant Capacity (TAC) was estimated by Ferric Reducing Antioxidant Power (FRAP) assay. It was observed that statistically significant increase in MDA levels in CRF patients correlating positively with creatinine and BUN and significant decrease in TAC in CRF patients correlating negatively with creatinine and BUN. Significant negative correlation was observed between MDA and TAC in CRF patients which is suggestive of increased lipid peroxidation and depletion of antioxidants causing an imbalance between OFR and TAC leading to progressive renal injury. This study would be beneficial to identify patients with increased risk of CRF and also for monitoring and optimization of antioxidant therapy.

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