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Asian Journal of Biochemistry
Year: 2008  |  Volume: 3  |  Issue: 2  |  Page No.: 118 - 125

Rehabilating Activity of Mangiferin in Benzo(a) Pyrene Induced Lung Carcinogenesis

Peramaiyan Rajendran, Ramachandran Venugopal, Ganapathy Ekambaram, Arumugam Aadithya and Dhanapal Sakthisekaran    

Abstract: Cancer chemoprevention involves prevention, delay, or reversal of the process of carcinogenesis through ingestion of dietary or pharmaceutical agents. A large number of potential chemopreventive agents are known, some of which have proven effective in clinical trials. These agents may function by a variety of mechanisms, directed at all major stages of carcinogenesis. One mechanism of particular note involves the inhibition of biosynthesis; of polyamines such as spermine, spermidine and putrescine are promising drug for chemoprevention. In the present study we evaluate chemopreventive efficacy of mangiferin against Benzo(a)Pyrene (B(a)P) induced lung carcinogenesis. Male Swiss albino mice strains were selected for the present investigation. Lung carcinoma was induced with B(a) P (50 mg kg-1 body weight, orally) and the treatment was started by the oral administration of mangiferin (100 mg kg-1 body weight). The modulatory effect of the mangiferin was examined on lung and liver to evaluate the level of polyamines, protein carbonyl, nucleic acid content and lipid peroxidation. Mangiferin significantly decreased the levels of polyamines, protein carbonyl, nucleic acid content and lipid peroxidation that were found to be increased in lung cancer bearing animals. Mangiferin could effectively inhibit B(a)P-induced lung carcinogenesis in albino mice by offering protection from protein damage and also by suppressing cell proliferation.

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