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Asian Journal of Biochemistry

Year: 2007  |  Volume: 2  |  Issue: 5  |  Page No.: 359 - 363

The Effects of Boswellia dalzielii (Burseraceae) Aqueous Bark Extract on Rat Liver Function

Roseline Aliyu, Donatien Gatsing and Kiri H. Jaryum

Abstract

The effect of the aqueous bark extract of Boswellia dalzielii (Burseraceae) on liver function was investigated using female Wistar rats. Graded concentrations of 0, 50, 100, 150 and 200 mg kg-1 body weight, of the aqueous bark extract of the plant sample were administered to the rats through gastric route and alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase activities, total protein, albumin and bilirubin (total, conjugated and unconjugated) were determined in the serum. Phytochemical screening of the extract was also done. The extract of B. dalzielii was found to have no significant (p>0.05) effect on total protein and albumin content at the end of the 5 days treatment period. Total bilirubin and alkaline phosphatase activities did not show any significant (p>0.05) difference as compared with the control. However, unconjugated bilirubin was found to decrease significantly (p<0.05) with increased dose of extract. These results seem to suggest no damage to hepatocytes as a result of the exposure to the plant bark extract. Moreover the transaminase activities seem to corroborate this, since they decreased significantly (p<0.001) with increase in the concentration of extract, as compared to control values, suggesting that B. dalzielii bark extract may strengthen the liver. The presence of flavonoids further gives credence to the hepato-strengthening activity of B. dalzielii bark extract.

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