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Asian Journal of Biochemistry
Year: 2007  |  Volume: 2  |  Issue: 5  |  Page No.: 323 - 329

TAME-Esterase and Oxidative Stress Contribute to Dysmetabolic Syndrome in Dyslipidaemia

A.H. Subratty, L.H. Semfa and M.D. Manraj    

Abstract: In this study, the level of oxidative stress and TAME-esterase activity in dyslipidaemic patients were studied. Fasting levels of total peroxides, triglycerides, total cholesterol, HDL-cholesterol, fasting and 2 h post load glucose were determined using commercially available kits among 110 individuals (mean age 47.5±8.5 years) subdivided into 3 groups namely: Optimal LDL (LDL<3.4 mmol L-1), Borderline LDL (3.4 = LDL = 4.2 mmol L-1) and High LDL (LDL>4.2 mmol L-1). TAME-esterase activity was assessed using a simple colorimetric micromethod. Data was analysed using Epi-Info statistical software. Analysis of data showed no association between TAME-esterase activity, total peroxides and dyslipidaemia. TAME-esterase activity was higher in patients with abnormal glucose metabolism as compared to normoglycaemic subjects (p<0.05). It was concluded that TAME-esterase and hence the kinin-kallikrein system may play an important role in insulin resistance and endothelial dysfunction.

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