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Asian Journal of Biochemistry

Year: 2007  |  Volume: 2  |  Issue: 4  |  Page No.: 274 - 278

Serum Paraoxonase Activity and Protein Thiols in Chronic Renal Failure Patients

Jeevan K. Shetty, Mungli Prakash, Sudeshna Tripathy, Manish Verma, Nagaraj K. Shashidhar and Pampapathy Sureshbabu


Serum paraoxonase is known to prevent low-density lipoprotein oxidation and atherogenesis. Relation of paraoxonase with severity of renal failure and protein thiols are studied in the current research. Serum paraoxonase, protein thiols, lipid hydroperoxides, creatinine and urea were estimated by spectrophotometric methods in chronic kidney disease patients on conservative management and in healthy controls. Lipid hydroperoxides, creatinine and urea levels were higher, protein thiols and paraoxonase activity were lower in patients compared to healthy controls. Creatinine correlated positively with lipid hydroperoxides and negatively with protein thiols and paraoxonase activity. In conclusion, paraoxonase activity is decreased with increase in severity of renal failure.

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