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Asian Journal of Biochemistry

Year: 2006  |  Volume: 1  |  Issue: 3  |  Page No.: 224 - 235

Biochemical Studies on Hepatocytes after Immunization of Mice with Schistosomal Worm and Egg Antigens

A. Bashtar, S.A. Ahmed, A.M. Soliman and M.A. Hamed

Abstract

This study has been carried out to investigate the most important aspects of metabolic integration between Schistosoma parasite and its final host under the influence of immunization with S. mansoni antigens. The possible side-effects of soluble worm antigen preparation (SWAP) and soluble egg antigens (SEA) were investigated through estimation of succinate dehydrogenase, lactate dehydrogenase, glucose-6-phosphatase, acid phosphatase and 5`-nucleotidase enzymes activities in hepatocytes of mice. Further, liver function enzymes as aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were estimated. Cells viability, no of worm burden and ova count were also investigated. The study has revealed that immunization with S. mansoni antigens protect against schistosomiasis by different degree of protection without any side-effects lead to improvement of liver enzymes under study.

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