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Asian Journal of Animal and Veterinary Advances
Year: 2017  |  Volume: 12  |  Issue: 3  |  Page No.: 123 - 131

RNAi Mediated Transgenesis for Improving Animal Produce

Lakshman Santra, Saurabh Gupta, Ajay Kumar Singh, Manish Mahawar, Ravikumar Gandham and Sujoy K. Dhara    

Abstract: The RNA interference is an established phenomenon of eukaryotic gene silencing. Recent advancement of genetic engineering allows employ this powerful tool for silencing multiple genes in several domestic animals and thus adds an additional dimension to animal welfare and livestock product improvement. This study reviews the current state of and prospects for the development of transgenic livestock using the mighty tool RNAi. The mini review accesses and summarizes information available in listed references. It starts with brief introduction to basis of RNA interference followed by outlining the current application of RNAi mediated transgenesis in livestock sector and identifies potential ways of developing and improving genetically modified livestock produces. This mini review explains importance of RNAi as a tool for improving animal produce. Here we present highlights of different recent studies that describe gene silencing by RNAi as an intervention tool for improvement of quality of various animal produces, acceleration of postnatal body growth, protection of livestock animals from certain fatal diseases etc. Diverse approaches are described to identify potential ways of developing genetically modified livestock. Further, this study emphasizes on recent advances in the field of gene targeting mentioning briefly on diverse molecular scissors and their potential involvement in executing conditional knock out or shRNA mediated knockdown strategies. Overall this mini review provides an update of the current status of harnessing RNAi for intended livestock produce and also points to the trend of future transgenic animal husbandry towards making the concept of ‘an animal for all purpose’ to come into reality.

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