Abstract: Objective: The aim of current study was to evaluate the therapeutic and high doses of florfenicol (FFC) on hematological values in goats. Methodology: Goats were intramuscularly induced with therapeutic (20 mg kg ^–1 b.wt.) and high doses (40 and 60 mg kg ^–1 b.wt.) of florfenicol for 3 days with 24 h interval. The blood samples were drawn at different timings from 0-120 h after drug administration and were assayed for the selected hematological parameters. Results: The therapeutic dose of FFC produced no effect on erythrocytes, hemoglobin, packed cell volume and leukocytes indices at all timing points, whereas decreased the lymphocyte count (p<0.05) at 24 h. The high dosages of FFC produced significant effect on erythrocytes, hemoglobin, packed cell volume, leukocytes and lymphocyte indices. In comparison with control, erythrocytic count and hemoglobin level (p<0.05) decreased from 48-72 h. Packed cell volume was observed to be reduced (p<0.05 and p<0.01) for 72 h. The leukocytic count (p<0.05) diminished from 24-72 h. The lymphocytic count decreased (p<0.05 and p<0.01) for 96 h. Clinically, local discomfort, reactions and pain at site of injection and some digestion disturbance were also noticed with high doses of florfenicol during experiment. Conclusion: It was concluded that both the therapeutic and high doses of florfenicol significantly affects the lymphocytes. The high doses of FFC produced anemic and immunosuppressive effects of drug.