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Asian Journal of Animal and Veterinary Advances
Year: 2015  |  Volume: 10  |  Issue: 9  |  Page No.: 509 - 517

Cancer Stem Cells: Concepts and Therapeutic Implications

Mudasir Bashir Gugjoo, Amarpal, Prakash Kinjavdekar, Hari Prasad Aithal, Abhijit Motiram Pawde, Deepti Bodh and Gutulla Taru Sharma    

Abstract: The cancer stem cell concept is currently seen as an important breakthrough in cancer research and relies upon the availability of the cancer stem cells. The cells have capability to produce whole tumor mass through self-renewal and differentiation besides, the ability to metastasize possibly through homing. Since such properties are also expressed by the normal stem cells, more research is needed in this field, especially in isolation and characterization. As the conventional therapies are effective only against the bulk of the tumor without any effect on cancer stem cells, it normally relapses. It seems logical to target the cancer stem cells through direct or indirect means along with the conventional therapies, in order to devise effectual therapeutics for cancer. The current review briefly throws light upon the development of the cancer stem cell theory and its concepts besides the possible therapeutic implications.

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