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Asian Journal of Animal and Veterinary Advances

Year: 2015  |  Volume: 10  |  Issue: 9  |  Page No.: 443 - 460

Plants as Future Source of Anti-Mycobacterial Molecules and Armour for Fighting Drug Resistance

Brajesh Singh, Mukta Jain, S.V. Singh, Kuldeep Dhama, G.K. Aseri, Neelam Jain, Manali Datta, Neeraj Kumar, Parul Yadav, Sujata Jayaraman, Saurabh Gupta, Kundan Kumar Chaubey and Jagdip Singh Sohal


Mycobacteria are dreadful human and animal pathogens causing range of mycobacterioses in different tissues. Due to their cell wall composition and their adaptability mycobacteria can survive in different habitats for years. Emergence of Multi-drug Resistant (MDR) and extensively drug resistant (XDR) strains has complicated the problem of mycobacterial disease control. Therefore new drugs should evolve to fight drug resistance. Medicinal plants may offer a new hope as source of bioactive molecules for developing alternative medicines for the mycobacterial diseases. Presently used anti-mycobacterial medicines produce serious side-effects and cannot be used in animals because of risk of entry into food chain. Plant derived medicines may help solving this problem and fighting the drug resistance. The present study reviews the literature available on anti- mycobacterial plants and their bioactive molecules with hope that this effort will expedite the research on development of a novel plant derived drugs against mycobacterial diseases.

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