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Asian Journal of Animal and Veterinary Advances
Year: 2015  |  Volume: 10  |  Issue: 3  |  Page No.: 132 - 140

Changes in Malate Dehydrogenase, Lactate Dehydrogenase and M/L Ratio as Energy Metabolism Markers of Acute Weight Gain

Y. Okada, K. Kawasumi, N. Mori, I. Yamamoto and T. Arai    

Abstract: Obesity is associated with the metabolic syndrome, diabetes, hypertension and chronic inflammation and early detection of weight gain and prompt intervention are the keys to promoting increased quality of life and longevity in veterinary animals. We evaluated the changes in Malate Dehydrogenase (MDH), Lactate Dehydrogenase (LDH) and MDH/LDH ratio as energy metabolism markers in dogs before and after the 4-week overfeeding trial. The acute weight gain was attained by overfeeding of 2x Daily Energy Requirement (DER) separated into 3 meals/day (overfed group). The experimentally overfed dogs showed about 28.2% increase in the Body Weight (BW), the increase of Body Condition Score (BCS) from 1.9-3.4 and significant elevations were noted in Triglyceride (TG), total cholesterol (TC), glucose (GLU) alkaline phosphatase (ALP), Blood Urea Nitrogen (BUN), leukocyte MDH and LDH. Although not significant, both the plasma MDH and LDH activities decreased, whereas leukocytic MDH and LDH activities increased in the overfed group after the feeding trial. Both the resultant plasma and leucocytic M/L ratios showed mild increase in the over-fed group after the feeding trial. In conclusion, assays of MDH, LDH and M/L ratio on plasma and leukocytes are not sensitive as diagnostic tools for detecting acute weight gain. The diagnostic significance of the above mentioned parameters should be further examined on various types of weight gain and target tissues.

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