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Asian Journal of Animal and Veterinary Advances

Year: 2012  |  Volume: 7  |  Issue: 3  |  Page No.: 210 - 224

A Review on the Potential Benefits of Phosphodiesterase Inhibitors in Various Models of Toxicities in Animals

Sima Ghiasi, Sindokht Ghiasi and Mohammad Abdollahi


Phosphodiesterase (PDE) enzymes are presented in nearly all cells and inhibitors of these enzymes have various pharmacological properties including cardiotonic, vasodilator, smooth muscle relaxant, antidepressant, antithrombotic, bronchodilator, anti inflammatory and enhancer of cognitive function. According to their different usage and the wide expression of PDE enzyme in the body screening the applications of PDE inhibitors (PDEI) may help to find effective pharmacological therapy with the least adverse effect for treatment of different toxicities. In this study we reviewed the protective effects of PDEI in different toxicities caused by toxins or drugs including cardiovascular toxicity, neurotoxicity, hepatotoxicity, nephrotoxicity, gastric mocusal damage and their beneficial role in inflammatory bowel disease and diabetes melitus. Most of included studies were in animal. Results indicate that 3 families of PDEIs (3, 4, 5) are the most common drugs that have been used as compared to other types of PDEIs in treatment of toxicities. It is required to conduct human and clinical examinations on anti-toxicity effects of PDEIs.

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