Abstract: Three types of common and one commercial antifungal drugs were tested in vitro for assessing their effectiveness against dermatophytic fungi Trichophyton verrucosum using a microdilution assay of the NCCLS (M38-P) standard for filamentous fungi with slight modifications. Four agents of antifungal drugs in different concentrations defined as local mixture [consisting of cupric sulfate and calcium oxide (quicklime) by a mixture proportion of 1:1 in concentration of 80.0 mg mL^-1], Hydrogen Peroxide mixture in concentration of 180.0 mg mL^-1, 10% Formaldehyde mixture in concentration of 39.0 mg mL^-1 and Amphotericin B (AMB) in concentration of 2.0 mg mL^-1. The results showed that there is a discrepancy among the antifungal drugs on the impact of dermatophytic fungi Trichophyton verrucosum. The order of effectiveness of four antifungal drugs against dermatophytic fungi was AMB with a Minimum Fungicidal Concentration (MFC) (MFC_90% = 2.0 μg mL^-1)> 10% Formaldehyde mixture with a concentration of (MFC_90% = 3.9 μg mL^-1)> Hydrogen Peroxide mixture with a concentration of (MFC_90% = 18.0 μg mL^-1)> the local mixture with a concentration of (MFC_90% = 80.0 μg mL^-1). In conclusion, AMB with a Minimum Fungicidal Concentration (MFC) (MFC_90% = 2.0 μg mL^-1) is the most effective drug against dermatophytic fungi under the climatic condition of AL-Ahsa, Saudi Arabia.