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Asian Journal of Animal and Veterinary Advances
Year: 2009  |  Volume: 4  |  Issue: 6  |  Page No.: 288 - 296

Isoflavone Aglycone from Fermented Soy Pulp Prevents Osteoporosis in Ovariectomized Rats

Go-Eun Hong, P.K. Mandal, Chang-Won Pyun, K. Choi, Soo-Ki Kim, Kyu-Ho Han, M. Fukushima, Ho-Chul Shin and Chi-Ho Lee    

Abstract: This study was done to investigate the effects of fermented soy pulp on the osteoporosis in ovariectomized rats. Sprague-Dawley female rats were randomly assigned to four groups as Sham Control (SC), Ovariectomized Control (OC), Ovariectomized and Soy Pulp (OSP) fed and Ovariectomized and Fermented Soy Pulp (OFSP) fed. All rats were fed on purified diets, supplemented with non-fermented and fermented soy pulp on basic diet for 7 weeks. It was observed that isoflavone aglycone was very high in soy pulp fermented for 12 h in comparison to non-fermented soy pulp. Body weight of the rats increased significantly (p<0.05) in comparison to other groups. Atrophy of uterus in OFSP group was significantly (p<0.05) prevented in comparison to OC group. The concentration of estradiol in OFSP group was higher than those of OC and OSP groups. The bone density in OFSP group was significantly (p<0.05) higher than those of OC and OSP groups. The histopathology indicated that OFSP group has better retarded the progress of osteoporosis than other groups. The results showed that isoflavone from the fermented soy pulp has prevented the osteoporosis in ovariectomized rats must be due to its estradiol like function. It is expected that the fermented soy pulp might serve as a functional food in osteoporosis of postmenopausal women.

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