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Asian Journal of Animal and Veterinary Advances
Year: 2006  |  Volume: 1  |  Issue: 1  |  Page No.: 1 - 12

Post-implantation Evaluation of the Natural Coral (Porites sp.) and Calcium Phosphate Cement in Sheep Femur: A Comparative Study

A.B.Z. Zuki, A. Fadilah, M. Zamri-Saad, M.Y. Loqman, Y. Norimah and H. Asnah    

Abstract: The present study was designed to evaluate and compare the natural coral and Calcium Phosphate Cement (CPC) post-implantation in sheep femoral bone. Twenty one adult, male sheep (weight 15-20 kg) were used in this study and were divided into two groups. Group one consists of 12 animals and implanted with natural coral while group two consists of 9 animals and implanted with CPC material. The large cortical defect (2.5x0.5x0.5 cm) was created surgically on the left proximal femur and replaced by the implant. Radiographs and ultrasonographs were obtained immediately after surgery and at 2, 4, 8 and 12 weeks post-implantation. Both ultrasonographs and radiographs taken at 8 and 12 weeks showed that the implants had been resorbed and left the space that much reduced in size. There was no sign of implant rejection observed in all animals. The sheep were euthanased at 2, 4, 8 and 12 weeks post-implantation and the bone examined grossly. Samples of the implant were taken for histological examination. Microscopically, natural coral exhibited rapid resorption and progressively replaced by new bone. At 8 weeks post-implantation, there was no more coral implant present and by week 12 the implant site was almost completely closed and filled by mature bone. Meanwhile, CPC implant was clearly seen and demonstrated only marginal bone formation at the end of 12 weeks study. The coral implant exhibited good bone substitute, but it has fast resorption rate. Thus, it may suitable for less compact bone with small defect.

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