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Asian Journal of Animal Sciences
Year: 2015  |  Volume: 9  |  Issue: 2  |  Page No.: 65 - 72

An Assessment of Serum Metabolites, Liver Enzymes Activities and Relative Organ Characteristics in Rabbits Fed Varying Levels of Chromolaena Odorata

U.G.S. Osa, J.A. Imasuen and S.O. Nwokoro    

Abstract: Biochemical and relative organ changes of rabbits fed with Chromolaena odorata Leaf Meal (COLM) were studied. A total of 32 rabbits consisting of 17 males and 15 females and of mixed breeds, aged 6-8 weeks and weighing 400-800 g were randomized into four diet groups of 0, 10, 20 and 30% in a completely randomized design for 56 days. Each treatment was replicated 4 times with two rabbits per replicate. Samples of blood were collected weekly from the ear vein for biochemical studies and the relative organ changes were determined using an electronic weighing scale. Results of biochemical analysis showed that the serum urea concentration was significantly (p<0.05) higher at an increasing level of COLM. Total cholesterol, triglycerides and LDL were found to significantly (p<0.05) decreased at increasing rate of COLM with the lowest level at 20 and 30% and corresponding to a value of 55.0 mg dL-1 at 20%, 25.0 mol L-1 at 30% and 22.5 mol L-1 at 20% for total cholesterol, triglycerides and LDL, respectively. As the rate of COLM increases, significant decrease was also observed in serum albumin concentration. Significant (p<0.05) increase observed in HDL was higher at 20% (60.5 mol L-1) than at 0% (42.0 mol L-1), 10% (24.0 mol L-1) and 30% (49.5 mol L-1) diet groups. Treatment with C. odorata significantly (p<0.05) prevented the elevation of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) with the lowest value at 10% for both serum transaminase. Results of relative organ changes showed higher significant (p<0.05) difference in the kidney and heart weight. However, significant decrease was observed in lungs and spleen weight at an increasing level of COLM. These results revealed that C. odorata may be safe and non-toxic only at a level that does not exceed 10% in the diet of rabbits.

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