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Asian Journal of Animal Sciences
Year: 2012  |  Volume: 6  |  Issue: 6  |  Page No.: 300 - 308

Cimicifuga racemosa Potentiates Antimuscarinic, Anti-adrenergic and Antihistaminic Mediated Tocolysis of Buffalo Myometrium

R. Rathore, A. Rahal and R. Mandil    

Abstract: Ethnoveterinary practices hold a promising scientific resource and can have far-reaching implications on economic development and enhancement of veterinary health care system. The present study was undertaken to evaluate the oxytocic/tocolytic activities of Cimicifuga racemosa (C. racemosa) roots extracts on isolated uterine strips of pregnant buffalo. Hot methanolic extraction of authenticated roots of C. racemosa was done using soxhlet extractor. Hot methanolic extract of C. racemosa roots was found to exert a myometrial relaxant effect which was potentiated after inhibition of excitatory muscarinic, alpha and beta adrenergic, H1-histaminergic and 5-HT receptors. Further studies are required on mechanistic aspects of tocolytic effect of C. racemosa particularly to elucidate the involvement of Ca2+ and K+ channels, NO and other signaling mechanisms including second messengers.

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