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Asian Journal of Animal Sciences
Year: 2011  |  Volume: 5  |  Issue: 6  |  Page No.: 381 - 386

Relationship of Serum Creatinine and Glomerular Filtration Rate by 99mTc-DTPA Scintigraphy in Dogs with Renal Failure

Mukesh Srivastava, Rajeev Vasantrao Gaikwad, Abdul Samad, Barkha Sharma and Ashish Srivastava    

Abstract: Glomerular Filtration Rate (GFR) is considered as the best single parameter for assessing renal function because it is directly proportional to the number of functioning nephrons. Serum creatinine is the most frequently measured analyze in clinical biochemistry as an indirect indicator of glomerular Filtration Rate (GFR). Renal scintigraphy has been used as direct measurement of the glomerular Filtration Rate (GFR) either of individual kidney or global (both kidneys). By this technique, the GFR is calculated by a regression equation relating the percent of the injected dose of radiopharmaceutical, technetium-99m Diethylene-Triaminepentaacetic acid (DTPA), taken up and filtered by the kidneys. This communication reports the relationship of direct (scintigraphy) and indirect (creatinine) methods of GFR measurement. Scintigraphy is a quick, noninvasive diagnostic technique in which a two-dimensional picture of internal body tissue is produced through the detection of the gamma radiation emitted by radioactive substances injected into the body within 15 min with a gamma camera. Serum creatinine increases in renal failure correlating with a decrease in GFR forming a curvilinear relationship. Based on the study undertaken in 44 dogs with renal failure, it was found that 86.36% dogs suffering from renal failure showed a conventional pattern of curvilinear relationship between creatinine and GFR. Inter-individual variations were observed in 11.36% of dogs. False positive results were obtained in 9% of total dogs, where creatinine was within normal reference range but GFR decreased on scintigraphic analysis. False negative observations were seen in 4.5% of dogs, where normal GFR with marginally high creatinine values was reported.

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