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Asian Journal of Applied Sciences
Year: 2009  |  Volume: 2  |  Issue: 4  |  Page No.: 341 - 347

Preparation of Organic Solvent/Surfactant-Free Microspheres of Methoxy Poly(Ethylene Glycol)-b-Poly(ε-Caprolactone) by a Melt Dispersion Method

Yodthong Baimark    

Abstract: Aim of this research is to prepare organic solvent and surfactant-free microspheres of biodegradable methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) diblock copolymer. The microspheres were produced in 90-100°C glycerol by melt dispersion method. Morphology of the microspheres was spherical in shape with rough surfaces. Almost microspheres were in the size range of 300-500 μm. Microsphere cross-sections showed condensed phases throughout the microsphere matrices. Melting temperatures and heats of melting of the MPEG-b-PCL were decreased in the microsphere form. In conclusion, the use of melt dispersion method results in organic solvent and surfactant-free biodegradable microspheres of diblock copolymer that showing a potentially useful drug delivery systems with free from surfactants and organic solvents.

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