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Asian Journal of Applied Sciences
Year: 2008  |  Volume: 1  |  Issue: 3  |  Page No.: 237 - 245

Preparation of Surfactant-Free and Core-Shell Type Nanoparticles of Methoxy Poly (ethylene Glycol)-b-Poly(ε-caprolactone-co-d,l-lactide) Diblock Copolymers

Yodthong Baimark, Yaowalak Srisuwan, Nuanchai Kotsaeng and Theeraphol Phromsopha    

Abstract: Methoxy poly(ethylene glycol)-b-poly(ε-caprolactone-co-D,L-lactide) diblock copolymers [MPEG-b-P(CL-co-DLL)] were synthesized by ring-opening polymerization of CL and DLL using MPEG with molecular weight of 5,000 g mol-1 and stannous octoate as the initiating system. Surfactant-free and core-shell nanoparticles of MPEG-b-P(CL-co-DLL) were prepared by modified-spontaneous emulsification solvent diffusion method without any surfactants. Influences of CL:DLL ratio of the diblock copolymers on nanoparticle characteristics were investigated and discussed. The sizes of colloidal nanoparticles obtained from light-scattering analysis were in the range of 84-639 nm. The nanoparticle size decreased with increasing the DLL ratio. Scanning and transmission electron micrographs indicated that the nanoparticles were spherical in shape and smooth surface. Core-shell structure of the nanoparticles consisting of the hydrophilic outer shell of MPEG and the hydrophobic inner core of P(CL-co-DLL) was confirmed by 1H-NMR spectroscopy.

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