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Acta Biochimica et Biophysica Sinica
Year: 2010  |  Volume: 42  |  Issue: 7  |  Page No.: 502 - 505

Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus

X Wu, X Shao, Z. Y Guo and C. W. Chi    

Abstract:

Neuropeptide Y (NPY) is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine conopeptides (designated as cono-NPYs) were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that some exocrine venom peptides are probably evolved from the preexisting endocrine peptides during the evolution of cone snails.

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