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Research Article

Enhanced Gastric Mucus Production by Syzygium guineense Leaf Extract Mediates is Antiulcer Properties

Asian Journal of Biological Sciences: Volume 12 (4): 765-771, 2019

Ifeoma Chinwude Ezenyi, Ruth Chigozirim Okechukwu, Gbenga Alex Alle, Solomon Ameh Fidelis and Oluwakanyinsola Adeola Salawu

Abstract

Background and Objective: Syzygium guineense (Myrtaceae) is a leafy forest tree with edible fruits and leaves found in many parts of Africa, where a decoction of its leaves have been used to treat wounds, diarrhea, rheumatism and infections. This study was performed to investigate the anti-ulcerogenic activity of Syzygium guineense ethanol leaf extract (SGLE) in experimental models of gastric ulceration. Materials and Methods: The gastro protective effect of SGLE (100, 200, 400, 800 and 1000 mg kg1) was evaluated in acidified ethanol-induced ulcers while doses of 400, 800 and 1000 mg kg1 SGLE were investigated in piroxicam induced ulcers. Its effect on gastric mucus concentration and gastric wall mucus was also determined using alcian blue, a mucus binding dye. Misoprostol (150 μg kg1) was used as control in all the experimental models. Results: At doses of 800 and 1000 mg kg1, SGLE produced significant (p<0.001) protective activity against acidified ethanol-induced gastric ulcers. It also caused a reduction in mean ulcer index and produced 58.1-88.6% protection against piroxicam-induced ulceration. These effects were comparable to those produced by misoprostol. SGLE was also observed to stimulate gastric mucus production, evoking 65.45-84.03% increase of mucus concentration in gastric content and 54.17-85.42% increase in mucus barrier of stomach. Histopathological findings showed a reduction of epithelial and vascular damage of stomach tissue in SGLE-treated group. Conclusion: Syzygium guineense possesses anti-ulcer effects and gastric mucus barrier and secretion may be implicated in these effects. It may also serve as a useful starting point for anti-ulcer drug development.

How to cite this article:

Ifeoma Chinwude Ezenyi, Ruth Chigozirim Okechukwu, Gbenga Alex Alle, Solomon Ameh Fidelis and Oluwakanyinsola Adeola Salawu, 2019. Enhanced Gastric Mucus Production by Syzygium guineense Leaf Extract Mediates is Antiulcer Properties. Asian Journal of Biological Sciences, 12: 765-771.

DOI: 10.3923/ajbs.2019.765.771

URL: https://scialert.net/abstract/?doi=ajbs.2019.765.771

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