Abstract: The leaves of Peperomia pellucida were studied with the aim of investigating the nutritional and phytochemical properties. Proximate composition and phytochemical properties were analyzed using standard procedures, while mineral compositions were determined with UV/Visible and atomic absorption spectrophotometers. Data were reported as mean of triplicates. Proximate analysis showed a high ash content; the crude fibre content was higher, while the carbohydrate content was observed to be the highest. Mineral analysis showed very low contents of manganese, iron, zinc and copper being the lowest, but high sodium content was observed. Phytochemical screening revealed the presence of alkaloids, cardenolides, saponins and tannins, while anthraquinones was observed to be absent. A result from this present study indicates an affirmation of the use of this plant in management of various ailments. The observed chemicals are responsible for its medicinal properties. The additive or synergistic action of these chemicals and their compounds at target sites associated with physiological process may be responsible for the beneficial effects exerted by Peperomia pellucida.