Science Alert
Pakistan Journal of Biological Sciences
  Year: 2015 | Volume: 18 | Issue: 1 | Page No.: 46-49
DOI: 10.3923/pjbs.2015.46.49
Acute and Cytotoxicity Studies of Aqueous and Ethanolic Leaf Extracts of Chromolaena odorata
R.N. Asomugha, A.N. Ezejiofor, P.N. Okafor and I.I. Ijeh

Chromolaena odorata, a commonly used traditional remedy for different ailments, believed to be quite safe in terms of toxicity was evaluated for acute toxicity and cytotoxic potentials. Acute toxicity was done on albino Wistar rats using the Lorke method while brine shrimps were used to test for cytotoxicity. The results showed that the estimated LD50 for the aqueous and ethanolic extracts was 2154 and >5000 mg kg-1 body weight, respectively. Cytotoxicity to brine shrimps showed LC50 values of 324 and 392 ppm for aqueous and ethanolic extracts, respectively. These results indicate the relative non toxic nature of Chromolaena odorata extracts.
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02 October, 2016
Nguyen Tam:
Hello I am a chemistry teacher in Vietnam I have read through the article about your research. "Acute and Cytotoxicity Studies of Aqueous Extracts of Chromolaena and Ethanolic Leaf odorata" It was great, I have found a lot of information from it. If you do not mind, could you please give me more information about your research. I need to refer it to guide a group of students to do scientific research. I think the results from this study will help us find some valuable medicinal products. Thank you very much! (Forgive me for using "google translate" to write to you)