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| Effects of Oral Vitamin C Supplementation on Anxiety in Students: A Double-Blind, Randomized, Placebo-Controlled Trial |
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Ivaldo Jesus Lima de Oliveira,
Victor Vasconcelos de Souza,
Vitor Motta
and Sergio Leme Da-Silva
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Abstract: Vitamin C (ascorbic acid) is a well-known antioxidant that
is involved in anxiety, stress, depression, fatigue and mood state in humans.
Studies have suggested that oxidative stress may trigger neuropsychological
disorders. Antioxidants may play an important therapeutic role in combating
the damage caused by oxidative stress in individuals that suffer from anxiety.
In this context, it was hypothesized that oral vitamin C supplementation would
reduce anxiety. However, few up to date studies have evaluated the consequences
of oral vitamin C supplementation on anxiety in humans. The present study examined
the effects of oral vitamin C supplements in 42 high school students, in a randomized,
double-blind, placebo-controlled trial. The students were given either vitamin
C (500 mg day-1) or placebo. Plasma concentrations of vitamin C and
blood pressure were measured before the intervention and then one day after
the intervention. Anxiety levels were evaluated for each student before and
after 14 days following supplementation with the Beck Anxiety Inventory. Results
showed that vitamin C reduced anxiety levels and led to higher plasma vitamin
C concentration compared to the placebo. The mean heart rates were also significantly
different between vitamin C group and placebo control group. Present study results
not only provide evidence that vitamin C plays an important therapeutic role
for anxiety but also point a possible use for antioxidants in the prevention
or reduction of anxiety. This suggests that a diet rich in vitamin C may be
an effective adjunct to medical and psychological treatment of anxiety and improve
academic performance. |
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07 October, 2016
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