Abstract: Grasscutter contributes to both the local and export earnings of most countries in Sub-Saharan Africa. At the local market level, for example, approximately 73 tons of grasscutter meat representing more than 15, 000 animals can be sold in a year. According to recent survey, the grasscutter continues to dominate the bush meat trade. However, international trade as well as regional and continental interests in the grasscutter meat provides economic bases for the development of the grasscutter industry. The industry will be greatly enhanced through the establishment of breeding centres to provide stocks for farmers and other growers who will multiply its production and also provide additional source of income, desperately required in the quest to help the rural poor to meet their basic necessities and sustain their food security. Detailed information on the health and diseases of these rodents are reported here. Some of the disease agents include species of gastrointestinal helminthes (nematodes, trematodes, cestodes and acanthocephala) and haemoparasites (Trypanosoma, Babesia and Plasmodium species).