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| Safety Evaluation of Prolonged Administration of Stresroak® in Grower Cockerels |
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A.A. Oyagbemi,
A.B. Saba
and R.O.A. Arowolo
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Abstract: Stresroak® is a herbal preparation from combination of Phyllatus emblica,
Ocimum sanctum, Withania, somnifera, Mangefira indica and Shilajit species. The
Ayurvedic drug is used as anti-stress, immunomodulator, adaptogen and performance
enhancer in poultry management. with outstanding results. The toxicological effects
of prolonged administration of Stresroak in grower Cockerels was evaluated using
haematological parameters and serum biochemical assay. Sixty growing Cockerels
were used in this study. The birds were randomly but equally divided into 5 groups.
Birds in groups A, B, C and D were administered with 109.8mg 292.8mg, 585.6mg
and 951.6mg of the drug dissolved in 2 litres of distilled water, daily for 60
days respectively. While the dose of group A was recommended by the drug manufacturer,
the birds in group E were administered with 0.9% Physiological saline. The haematological
parameters analyzed were total red blood cell (RBC) count, total white blood cell
(WBC) count, haemoglobin concentration (Hb), platelets count and heterophil/lymphocytes
ratio. Plasma enzymes and proteins analyzed were total proteins (T.P), albumin
(ALB), globulin (GLO), fibrinogen (FIB), total bilirubin (T.Bil), alkaline phosphatase
(ALP), aspartate aminotransferase (AST), alanine Aminotransferase (ALT) and gamma
glutamyltransferase (GGT). Stresroak generally improved haematological parameters
in chicken administered with the drug when compared with the chicken in the control
group. The significant (P< 0.05) increase in total RBC and WBC counts and MCH
both at 30 and 60 days post-administration especially for the therapeutic dose,
show that Stresroak® probably enhances erythropoiesis. Lower heterophil/lymphocyte
ratio was observed for the groups that received the highest doses of Stresroak®
and this was consistent throughout the course of the experiment, which implies
that the herbal preparation improved the immunity of the chicken. The plasma levels
of total protein, globulin, albumin and fibrinogen increased dose-dependently
both at 30 and 60 days post- Stresroak® administration. The plasma levels
of ALP and AST were significantly lowered while non-significant changes were observed
for plasma levels of ALT and GGT at 30 days post- Stresroak® administration.
Conversely, by 60 days post- Stresroak® administration, the plasma levels
of ALT and GGT were significantly (P< 0.05) elevated except in cockerels in
group A that received the recommended therapeutic dosage; where the plasma levels
was observed to be lower for ALP (P< 0.05) and AST (P>0.05). Histopathological
findings did not however reveal any damage to the liver or kidney. It was concluded
that Stresroak® exhibits haematinic, hepato-protective and immune stimulation
properties and is safest at its recommended therapeutic dose as it was found to
have potential tendency to cause hepatic injury when administered for longer period
and at higher dosages. |
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| COMMENTS |
19 May, 2012
imran abdulafeez adetunji:
that a very interesting title givin insite on phsiological activity in the birds |
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