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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 5 | Page No.: 428-431
DOI: 10.3923/ijp.2007.428.431
In vitro Antistaphylococcal Activity of the Extracts of Several Neglected Plants in Malaysia
Z.A. Zakaria, A.M. Mat Jais, M. Mastura, S.H. Mat Jusoh, A.M. Mohamed, N.S. Mohd. Jamil, M.S. Rofiee and M.R. Sulaiman

Abstract:
The present study was carried out to evaluate the antibacterial activity of the aqueous, methanol and chloroform extracts of several plants available in Malaysia, namely Muntingia calabura (L.), Melastoma malabathricum (L.), Bauhinia purpurea (L.), Corchorus capsularis (L.) and Dicranopteris linearis (L.) using the single screening in vitro microtiter plate dilution methods. The extracts, at the dose of 5 μg μL-1, were screened against various strains of Staphylococcus aureus, namely S. aureus 29213α, S. aureus 33591, S. aureus 700699, vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA). Results: Interestingly, only the methanol extracts of D. linearis exhibited an antibacterial activity against all strains of S. aureus whereas all extracts of M. calabura were effective only against the S. aureus 29213α, S. aureus 33591 and S. aureus 700699. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) for D. linearis range between 0.625-1.250 and 1.250-2.500 μg μL-1, respectively whereas for the M. calabura extracts the MIC and MBC range between 1.250-5.000 and 2.500-5.000 μg μL-1, respectively. Although the other plants gave negative results in this study, their potential antibacterial properties should not be disregarded as the present study was carried out using only one low concentration (5 μg μL-1) and that the activity was determined using crude, but not pure, extracts. The present study demonstrated the potential of chloroform extract of D. linearis, which indicate the present of non-polar bioactive compounds, as VRSA antibacterial agents and all extracts of M. calabura as a potential source of antibacterial agents for the treatment of normal S. aureus infection.
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COMMENTS
28 May, 2014
Akinjogunla O.J:
Dear Editor, This is a very good paper. Keep it up Akinjogunla, O.J (Ph.D)
 
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