Abstract: This study was designed to associate Blood Lead Concentration(BLC), reproductive disorders and oxidant/antioxidant status in female buffaloes reared besides high ways. Animals were clinically examined and blood samples were collected from 30 non pregnant female buffaloes for assaying of lead and some oxidant/antioxidant values. According to BLC, animals were divided into two groups. The high BLC group showed high incidence of reproductive disorders in form of inactive ovaries, delayed puberty, endometritis, repeat breeding, mastitis, persistent corpora lutea and abortion. Malondialdehyde (MDA) and Nitric Oxide (NO) values increased, while, Total Antioxidant Activity (TAA), Superoxide Dismutase (SOD), Glutathione Reduced (GR) and Selenium (Se) values decreased in buffaloes of high BLC. It was concluded that there is a tight relationship between blood lead concentration, reproductive disorders and oxidant/ antioxidant imbalance in buffaloes.