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Asian Journal of Developmental Biology
  Year: 2009 | Volume: 1 | Issue: 1 | Page No.: 1-9
DOI: 10.3923/ajdb.2009.1.9
Stem Cells for Treating Ankylosing Spondylitis Disease
Sarder Nasir Uddin and Md. Eunus Ali

Abstract:
The aim of this study to find out and accumulate the possible way of recent treatments of ankylosing spondylitis specially by using Stem Cells. There is accumulating evidence that anti-tumor-necrosis-factor (anti-TNF) therapy is highly effective in SpA, especially in ankylosing spondylitis and psoriatic arthritis. In ankylosing spondylitis there is an unmet medical need, since there are almost no disease-modifying antirheumatic drugs available for severely affected patients, especially those with spinal manifestations. This review found that the replacement therapy of stem cells led to a new idea: by taking healthy stem cells from the developing goat`s bone marrow cells or human blastocyst and transplanting them into the affected area of a ankylosing spondylitis patient. The cell survives and they formed connections with the surrounding tissue. Transplantation strategies based on stem cells present enormous potential for repairing the damage caused by ankylosing spondylitis disease. Stems cells may also be preferable to other tissue, especially if they can be derived from the patient`s own body, avoiding potential immunological problems. So, stem cell replacement therapy for ankylosing spondylitis disease will some day become a therapeutic reality.
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COMMENTS
05 October, 2010
David Kelley:
I would be very interested in this treatment. I am 49 and have had this since I was at least 24. I also believe my trigger was a series of immunizations I received when I joined the Air Force. I wonder if you have any opinion on this previous comment. Anyway, I am at a very bad state right now. I now have constant pain in my feet and ankles, can't sleep, and I don't know how much longer I can stand the pain My doctor says there are 2 types of AS; the kind with fusing and deformity, and the kind that is mostly pain. Unfortunately I am fully in the pain category as I have very little fusing and appear normal, but the pain is so bad I am now on a morphine type pill, Humira, plus tons of other meds. I would appreciate any help you can give. Thank you.
 
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