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Trends in Bioinformatics
  Year: 2016 | Volume: 9 | Issue: 1 | Page No.: 14-22
DOI: 10.3923/tb.2016.14.22
 
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Assortment of Tachystatin B of Tachypleus tridentatus as a Stable Scaffold in Antifungal Peptide Design

B. Senthilkumar and R. Rajasekaran

Abstract:
Background and Objective: Global increase in microbial infections has steered the production and improvement of antimicrobial and antifungal peptide drugs in pharmaceutical firm. In this study, structural stability of the antifungal peptide tachystatin B1 (2DCV) and B2 (2DCW) of Tachypleus tridentatus was computationally investigated. Materials and Methods: Static structure analysis showed high number of intra-molecular interactions in tachystatin B2 than B1 comparatively. Further, conformational sampling studies revealed tachystatin B2 to be structurally stable, substantiated by various structural events like root mean square deviation, ramachandran plot, radius of gyration, ovality and lipophilicity. Results: Moreover, the statistically validated contours of surface area, polar surface area, non polar surface area, hydrogen bond distribution and intra distance of disulfide bridges also supported the priority of tachystatin B2 with respect to stability. Conclusion: In this study, it is proposed that tachystatin B2 could be an efficient template for scaffolding antifungal peptide drugs.
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How to cite this article:

B. Senthilkumar and R. Rajasekaran, 2016. Assortment of Tachystatin B of Tachypleus tridentatus as a Stable Scaffold in Antifungal Peptide Design. Trends in Bioinformatics, 9: 14-22.

DOI: 10.3923/tb.2016.14.22

URL: https://scialert.net/abstract/?doi=tb.2016.14.22

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