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Trends in Applied Sciences Research
  Year: 2009 | Volume: 4 | Issue: 2 | Page No.: 107-115
DOI: 10.3923/tasr.2009.107.115
 
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Methoxy Poly (Ethylene Glycol)-b-Poly (D, L-lactide) Films for Controlled Release of Ibuprofen

T. Phromsopha and Y. Baimark

Abstract:
Biodegradable films of methoxy poly (ethylene glycol)-b-poly (D, L-lactide) diblock copolymers (MPEG-b-PDLL) containing drug were prepared by solution casting of MPEG-b-PDLL and drug in dichloromethane. Ibuprofen was used as a poorly-water soluble model drug. Influences of MPEG-b-PDLL/drug ratio and film thickness on ibuprofen-loaded film characteristics and drug release behaviors were investigated. The hydrogen bonding between MPEG-b-PDLL and drug were detected from FTIR analysis. From FTIR and differential scanning calorimetric results indicated that the ibuprofen was well distributed throughout the MPEG-b-PDLL film matrices. The drug release rates increased as the drug ratio increased and the film thickness decreased. The drug release from the films occurred by drug diffusion mechanism.
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How to cite this article:

T. Phromsopha and Y. Baimark, 2009. Methoxy Poly (Ethylene Glycol)-b-Poly (D, L-lactide) Films for Controlled Release of Ibuprofen. Trends in Applied Sciences Research, 4: 107-115.

DOI: 10.3923/tasr.2009.107.115

URL: https://scialert.net/abstract/?doi=tasr.2009.107.115

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