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Synaptamine (SG8839),™ An Amino-Acid Enkephalinase Inhibition Nutraceutical Improves Recovery of Alcoholics, A Subtype of Reward Deficiency Syndrome (RDS) |
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Kenneth Blum,
Thomas J.H. Chen,
B.W. Downs,
Brian Meshkin,
Seth H. Blum,
Manuel Martinez Pons,
Julie F. Mengucci,
Roger L. Waite,
Vanessa Arcuri,
Michael Varshofsiky and Eric R. Braverman |
Abstract:
The present research was conducted to test the hypothesis that manipulation of the reward neural circuitry by utilization of oral and intravenous amino-acid–enkephalinase therapy would improve both the emotional and behavioral symptomology of recovering 600 alcoholics in an open trial clinical study. Our findings suggest that the combination of both oral and intravenous administration of SG8839 significantly improved both the emotional and behavioral recovery of the alcoholic subjects when compared to pre and post administration scores, including reduction of craving (p<0.001), reduced depression (p<0.001), reduced anxiety (p<0.001), anger (p<0.001), fatigue (p<0.001), lack of energy (p<0.001) and crisis (p<0.001). Mean reductions for anxiety (53.8±10.2%), craving (76.3±3.1%), depression (61.0±6.3%), fatigue (76.9±3.1%) and crisis (53.8±5.5%) were all significantly greater than 50% (p<0.001). This is the first study combining both oral and intravenous solutions suggesting clinical improvement.
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How to cite this article:
Kenneth Blum, Thomas J.H. Chen, B.W. Downs, Brian Meshkin, Seth H. Blum, Manuel Martinez Pons, Julie F. Mengucci, Roger L. Waite, Vanessa Arcuri, Michael Varshofsiky and Eric R. Braverman, 2007. Synaptamine (SG8839),™ An Amino-Acid Enkephalinase Inhibition Nutraceutical Improves Recovery of Alcoholics, A Subtype of Reward Deficiency Syndrome (RDS). Trends in Applied Sciences Research, 2: 132-138.
DOI: 10.3923/tasr.2007.132.138
URL: https://scialert.net/abstract/?doi=tasr.2007.132.138
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