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Trends in Applied Sciences Research
  Year: 2006 | Volume: 1 | Issue: 6 | Page No.: 627-633
DOI: 10.3923/tasr.2006.627.633
 
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Schistosomicidal Effect of Curcumin

Mahmoud EL-Sherbiny, Mohamed M. Abdel-Aziz , K.A. Elbakry , E.A. Toson and A.T. Abbas

Abstract:
Swiss albino mice infected with 100 cercariae of S. mansoni were orally treated with a single dose of 20 mg curcumin per kg of body weight and second group was treated with a triple dose, day after day, of 250 mg praziquantel (PZQ) per kg of body weight. The curcumin and PZQ-treated groups revealed a significant (p<0.0001) reduction (67.3 and 83.97%, respectively) of worm burden compared to controls. Also, total IgG antibodies against Soluble Worm Antigen Preparations (SWAP) were significantly decreased after treatment with curcumin (p<0.05) compared to infected untreated group. Furthermore, the serum levels of gamma interferon (IFN-γ) and interleukine-2 (IL-2) were significantly (p<0.05) decreased in curcumin-treated group. Finally, the serum activity of Glutamic Pyruvic Transaminase (GPT) was significantly (p<0.05) decreased in curcumin-treated group but not in PZQ-treated group. These results indicate that curcumin may represent a new inexpensive and effective schistosomicidal drug.
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How to cite this article:

Mahmoud EL-Sherbiny, Mohamed M. Abdel-Aziz , K.A. Elbakry , E.A. Toson and A.T. Abbas , 2006. Schistosomicidal Effect of Curcumin. Trends in Applied Sciences Research, 1: 627-633.

DOI: 10.3923/tasr.2006.627.633

URL: https://scialert.net/abstract/?doi=tasr.2006.627.633

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