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  1. Research Journal of Phytochemistry
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Research Journal of Phytochemistry

Year: 2011 | Volume: 5 | Issue: 2 | Page No.: 80-88

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Authors


Mohammad Ahmad Khasawneh

Country: UAE

Hanan Mohamed Elwy

Country: UAE

Nael Mohamed Fawzi

Country: UAE

Alaaeldin Ahmed Hamza

Country: UAE

Abdul Raheem Chevidenkandy

Country: UAE

Ahmed H. Hassan

Country: UAE

Keywords


  • polyphenolic compounds
  • lipoxygenase inhibitory effects
  • Medicinal plants
  • MTT assay
  • anticancer activity
  • antioxidant activity
  • Calotropis procera
Research Article

Antioxidant Activity, Lipoxygenase Inhibitory Effect and Polyphenolic Compounds from Calotropis procera (Ait.) R. Br

Mohammad Ahmad Khasawneh, Hanan Mohamed Elwy, Nael Mohamed Fawzi, Alaaeldin Ahmed Hamza, Abdul Raheem Chevidenkandy and Ahmed H. Hassan
The purpose for this study was to evaluate the biological, antioxidant, anti-inflammatory and anti-cancer properties of Calotropis procera alcoholic extract and its various solvent subfractions. The total antioxidant property was estimated by the Ferric Reducing Antioxidant Power (FRAP), 1,1-diphenyl-2-picrylhydrazyl (DPPH·), 2, 2-azino-bis (3-ethylbenzothiazoline-6-sulfonate) (ABTS·+) and β-carotene bleaching tests. Among the ethanol extract and three fractions, the ethyl acetate fraction showed the highest phenolic content (108.26 mg gallic acid g-1) and the best antioxidant activity. The ascorbic acid equivalent antioxidant capacities of the ethyl acetate fraction were 0.26, 0.53, 0.17 mmol g-1 in FRAP, ABTS and DPPH assays, respectively. This study verified that the ethanol extract and ethyl acetate fraction from Calotropis procera have strong antioxidant activity that were correlated their high level of phenolic content. Furthermore, the same extract showed appreciable anti-inflammatory via lipoxygenase inhibitory activity (LOX), IC50 values ranged from 7.12-52.68 μg mL-1. Moreover, ethyl acetate fraction showed the strongest cytotoxic effect (IC50 = 10.6 μg mL-1) against MCF-7 breast cancer cell line.
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How to cite this article

Mohammad Ahmad Khasawneh, Hanan Mohamed Elwy, Nael Mohamed Fawzi, Alaaeldin Ahmed Hamza, Abdul Raheem Chevidenkandy and Ahmed H. Hassan, 2011. Antioxidant Activity, Lipoxygenase Inhibitory Effect and Polyphenolic Compounds from Calotropis procera (Ait.) R. Br. Research Journal of Phytochemistry, 5: 80-88.

URL: https://scialert.net/abstract/?doi=rjphyto.2011.80.88

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