Mutagens are not only involved in genotoxicity and carcinogenesis but also involved in the inception and pathogenesis of several chronic degenerative diseases including hepatic disorders, neurodegenerative disorders, cardiovascular disorders, diabetes, arthritis, chronic inflammation and in the process of ageing. One of the best ways to minimize the detrimental effects of mutagens is by the use of natural antimutagens. Naturally occurring antimutagenic principles present in plants, human diet and other sources have protective effects against mutagens. These include flavonoids, phenolics, coumarins, carotenoids, anthraquinones, tannins, saponins and many more. Present review attempts to furnish a brief overview on natural products conferring antimutagenicity.