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Research Journal of Environmental Toxicology

Year: 2014 | Volume: 8 | Issue: 1 | Page No.: 46-52
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Authors

A.F. Ayorinde

B.O. Oboh

O.A. Otubanjo

A.C. Alimba

P.C. Odeigah

Keywords

Research Article

Some Toxicological Effects of a Commonly Used Mosquito Repellent in Lagos State, Nigeria

A.F. Ayorinde, B.O. Oboh, O.A. Otubanjo, A.C. Alimba and P.C. Odeigah
Although, toxicity of some mosquito repellents has been reported, effects of different doses on some parameters and different sexes is not clear. This study was aimed at determining the toxicity of a commonly used mosquito repellent in Lagos State, Nigeria. The effects studied in rats were based on some hematological parameters, body weight/organ indices (Relative organ weights) and histopathological analysis. The rats were divided into two groups of 6 males and 6 females each and a control of 2 males and 2 females. The two groups were exposed to one and two mosquito repellents per day for one, two and four weeks, respectively. Hematological analysis showed increase in White Blood Cell (WBC) counts in the females and males exposed for 2 weeks and above (p<0.05). Increase was also recorded in the percentage of Mixed Population of White Blood Cells (MXD%) of females and males rats exposed for 2 weeks and above (p<0.05). Platelets (PLT) counts in the female rats (after 2 weeks) also increased when compared with the control (p<0.05). For relative organ weights, significant difference was observed in relative spleen (p<0.05), heart (p>0.05) of both female and male animals and thymus (p<0.05) of the female animals only when compared with control. The histopathological studies showed a severe damage to the lungs whereas no damage was observed in the liver and kidney in both male and female rats. These results show that exposure to Black coil could be detrimental to health.
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