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Pakistan Journal of Biological Sciences
  Year: 2018 | Volume: 21 | Issue: 9 | Page No.: 441-447
DOI: 10.3923/pjbs.2018.441.447
 
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Biological Activity of Native and Low Molecular Weight Chitosan obtained by Steam Explosion Process
Dina Sugiyanti, Purnama Darmadji, Umar Santoso, Yudi Pranoto, Chairil Anwar and Sri Anggrahini

Abstract:
Background and Objective: Low molecular weight chitosan (LWCS) was interestingly used because of it’s solubility and has good functional properties like antioxidant and antibacterial activity. This study aimed to evaluate antioxidant and antibacterial activity of chitosan and low molecular weight chitosan. Materials and Methods: Low molecular weight chitosan was obtained by physical and chemical hydrolysis using steam explosion process with steam pressure at 6 bar, temperature at 160°C and concentration of phosphotungstic acid at 0.1% w/v. The antioxidant activity was confirmed by radical DPPH scavenging activity, chelating metal ion value, inhibitory lipid peroxidation and antibacterial activity was confirmed by diffusion methods. Results: LWCS had antioxidant activity higher than native chitosan on radical scavenging, chelating ion value and inhibition of lipid peroxidation. LWCS had higher inhibitory effect as antibacterial than native chitosan against tested bacteria, there were Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Streptococcus aureus and Bacillus subtilis. Conclusion: It was concluded that LWCS had more powerful antioxidant and antibacterial activity than native chitosan.
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How to cite this article:

Dina Sugiyanti, Purnama Darmadji, Umar Santoso, Yudi Pranoto, Chairil Anwar and Sri Anggrahini, 2018. Biological Activity of Native and Low Molecular Weight Chitosan obtained by Steam Explosion Process. Pakistan Journal of Biological Sciences, 21: 441-447.

DOI: 10.3923/pjbs.2018.441.447

URL: https://scialert.net/abstract/?doi=pjbs.2018.441.447

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