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Pakistan Journal of Biological Sciences

Year: 2016 | Volume: 19 | Issue: 1 | Page No.: 26-35
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Authors

Badr E. El-Bialy

Eman E. Abdeen

Nermeen B. El-Borai

Eman M. El-Diasty

Keywords

Research Article

Experimental Studies on Some Immunotoxicological Aspects of Aflatoxins Containing Diet and Protective Effect of Bee Pollen Dietary Supplement

Badr E. El-Bialy, Eman E. Abdeen, Nermeen B. El-Borai and Eman M. El-Diasty
Aflatoxins (AFs), widely distributed food-borne mycotoxins, affect quality and safety of food and cause economic losses in livestock. In this study, the protective effect of Bee Pollen (BP) against some immunotoxic hazards elucidated from eating of AFs-containing diet was investigated in Wistar rats. Rats were randomly classified into four groups and treated for 30 days, Group 1; control negative, Group 2; Total AFs (3 mg kg–1 basal diet), Group 3; BP (20 g kg–1 basal diet) and Group 4; AFs+BP in basal diet. The immunoprotective effect of BP was revealed in terms of increasing (relative to levels seen in Group 2 rats that consumed the AFs diet) serum total protein and globulin levels, restored normal neutrophil (PMN)/lymphocyte ratio, increased PMN phagocytic activity and increased lymphocyte proliferative capacity. Also, the use of the BP reduced spleen H2O2 levels and increased GSH content while maintaining normal levels of NO formation. Histopathologic analysis showed that the AFs caused lymphocytic depletion in the spleen; however, BP induced lymphocytic hyperplasia and reduced the levels of AFs-inducible cellular exhaustion or depletion. These results provide evidence of a protective effect of BP against some immunotoxic actions induced in situ by consumption of AFs.
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How to cite this article

Badr E. El-Bialy, Eman E. Abdeen, Nermeen B. El-Borai and Eman M. El-Diasty, 2016. Experimental Studies on Some Immunotoxicological Aspects of Aflatoxins Containing Diet and Protective Effect of Bee Pollen Dietary Supplement. Pakistan Journal of Biological Sciences, 19: 26-35.

DOI: 10.3923/pjbs.2016.26.35

URL: https://scialert.net/abstract/?doi=pjbs.2016.26.35

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